History of science is devoted to the history of science, medicine and technology from earliest times to the present day. Histories of science were originally written by practicing and retired scientists, starting primarily with William Whewell, as a way to communicate the virtues of science to the public.

Friday, September 26, 2014

Electrophoresis by Arne Tiselius

Arne Wilhelm Kaurin Tiselius (August 10, 1902 – October 29, 1971) firstly described electrophoresis in 1933. It is a technique for the separation of charged molecules.

The Tiselius tube, as it became known, made it practical to study protein mixtures particularly blood proteins.

Tiselius was awarded the 1948 Nobel Prize in chemistry for work with electrophoresis.

Tiselius was from University of Uppsala, Sweden, where he studied under Theodor Svedberg. Tiselius’s doctoral dissertation in 1930 was on the electrophoresis of proteins.

He then published expanded observations using the moving boundary method of electrophoresis in 1937, which led to his 1948 Nobel Prize in chemistry.

This technique was applied by Tiselius to analyze the composition of blood serum. Owing to this method, Tiselius was able to confirm the existence of different groups of protein including albumins, globulins and antibodies.

His technique made it possible for Linus Carl Pauling to demonstrate in 1949 that the sickle cell gene affects the hemoglobin.
Electrophoresis by Arne Tiselius


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